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Allosteric Modulation of Human Serum Albumin Induced by Peptide Ligand
文献类型:期刊
作者:Hou, Jingfei[1]  Peng, Jiaxi[2]  Yu, Yue[3]  Lin, Yuchen[4]  Liu, Changliang[5]  Duan, Hongyang[6]  Yang, Yanlian[7]  Wang, Chen[8]  
机构:[1]Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Standardizat & Measurement Nanotechno, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.,Univ Chinese Acad Sci, Beijing 100049, Peoples R China.;
[2]Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Standardizat & Measurement Nanotechno, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.,Univ Chinese Acad Sci, Beijing 100049, Peoples R China.;Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China.;
[3]Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Standardizat & Measurement Nanotechno, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.,Univ Chinese Acad Sci, Beijing 100049, Peoples R China.;
[4]Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Standardizat & Measurement Nanotechno, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.,Univ Chinese Acad Sci, Beijing 100049, Peoples R China.;
[5]Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Standardizat & Measurement Nanotechno, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.,Univ Chinese Acad Sci, Beijing 100049, Peoples R China.;
[6]Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Standardizat & Measurement Nanotechno, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.,Univ Chinese Acad Sci, Beijing 100049, Peoples R China.;Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China.;
[7]Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Standardizat & Measurement Nanotechno, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.,Univ Chinese Acad Sci, Beijing 100049, Peoples R China.;
[8]Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Standardizat & Measurement Nanotechno, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.,Univ Chinese Acad Sci, Beijing 100049, Peoples R China.;
通讯作者:Yang, YL; Wang, C (reprint author), Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Standardizat & Measurement Nanotechno, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.; Yang, YL; Wang, C (reprint author), Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
期刊名称:CHINESE JOURNAL OF CHEMISTRY影响因子和分区
年:2017
卷:35
期:8
页码:1270-1277
收录情况:SCI(E)(WOS:000407852800009)  
ISSN:1001-604X
关键词:human serum albumin; peptide ligands; allosteric modulation; structure-affinity relations; affinity-controlled delivery
所属部门:化学系
摘要:
Human serum albumin (HSA) is an abundant protein in plasma that can bind and transport many small molecules, and the corresponding affinity-controlled drug delivery shows great advantage in the biological system. Peptide SA06 is a reported ligand comprising 20 amino acids, and is known to non-covalently bind with HSA to extend the lifetime and improve the pharmacokinetic performance. The structural information of the HSA-peptide complex is keen for obtaining molecular insight of the binding mech ...More
学科:化学综合
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